Search Results for: Traction mechanism
svinkina t , heckl d , comer e , li x , ciarlo c , hartman e , munshi n , schenone m , schreiber sl , carr sa , ebert bl . author information brigham and women's hospital, boston, ma , usa. abstract lenalidomide is a drug with clinical efficacy in multiple myeloma and other b cell neoplasms, but its mechanism
substitution of ikzf conferred resistance to lenalidomide-induced degradation and rescued lenalidomide-induced inhibition of cell growth. similarly, we found that lenalidomide-induced interleukin- production in t cells is due to depletion of ikzf and ikzf . these findings reveal a previously unknown mechanism...
https://www.ncbi.nlm.nih.gov/pubmed/24292625