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a primary biological target of berberine. zang h ( ) wang yx ( ) the insr-up-regulating and glucoselowering activities of berberine has also been investigated in humans. a study involving a variety of human cell lines including cem, hct- , sw , ht , t, and hepatitis b virus-transfected human liver cells
showed that berberine increased insr messenger rna and protein expression in cultured cells kon wj ( ). in all studies, it was demonstrated that berberine caused an improvement in glucose tolerance and enhanced insulin action, thereby reducing insulin resistance. ko bs ( ), lee ys ( ), yi p ( ), chen...
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