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; rutz et al., ). interestingly, ccr - ilc co-express rorγt and the master regulator of type immunity, t-bet. t-bet is key to the differentiation of nkp + ccr - ilc s, as those cells fail to develop in mice lacking the gene encoding t-bet, tbx ( klose et al., ; rankin et al., ). importantly, t-bet not
moreover, exposure to pro-inflammatory cytokines, such as il- , il- and il- , was reported to further support transdifferentiation to an ilc -like fate ( vonarbourg et al., ; bernink et al., ; satoh-takayama et al., ). however, despite this, the intrinsic molecular mediators governing ilc plasticity have not...
https://elifesciences.org/articles/52549