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and multiple myeloma ). the esr is decreased in polycythemia , hyperviscosity , sickle cell anemia , leukemia , chronic fatigue syndrome , [ ] low plasma protein (due to liver or kidney disease) and congestive heart failure . although increases in immunoglobulins usually increase the esr, very high levels
conditions, fibrinogen , other clotting proteins, and alpha globulin are positively charged, thus increasing the esr. [ ] esr begins to rise at to hours after the onset of acute self-limited inflammation, decreases slowly as inflammation resolves, and can take weeks to months to return to normal levels...
https://en.wikipedia.org/wiki/Erythrocyte_sedimentation_rate