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important in the development and maintenance of female reproductive tissues such as the mammary glands , uterus , and vagina during puberty , adulthood , and pregnancy . [ ] it also has important effects in many other tissues including bone , fat , skin , liver , and the brain . though estradiol levels
decrease to very low levels. in addition to its role as a natural hormone, estradiol is used as a medication , for instance in menopausal hormone therapy ; for information on estradiol as a medication, see the estradiol (medication) article. contents biological function sexual development reproduction...
https://en.wikipedia.org/wiki/Estradiol