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response to experience — a molecular process widespread in the brain. mutations in setd a have primarily been found in people with schizophrenia, suggesting that this rare gene variation might hold important clues to the underlying disease process. to find out how such a mutation in setd a affects brain cells

schizophrenia. the mutated gene also disrupted the cellular machinery by which neurons communicate with each other. for example, it stunted the growth and branching of cell extensions and reduced the number of spines on these extensions, which are needed to relay chemical signals from neighboring cells...

https://www.nimh.nih.gov/news/science-news/2019/schizophrenia-risk-gene-linked-to-cognitive-deficits-in-mice.shtml