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, without using chemical doubling agents, have been observed to a limited extent, for nearly years. rates of spontaneous haploid genome doubling (shgd) have ranged from less than % to greater than %. recently, there has been increased interest to forgo chemical treatment and instead utilize this natural...
weeks oftreatment, demonstrating a statistically significant percentage point (p< ) improvement in ppfev in patients treated with trikafta compared to their baseline after a -week run-in oftreatment on ivacaftor or tezacaftor/ivacaftor. the study met all secondary endpoints, including a statistically...
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