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late-stage disease in gbm, melanoma, urothelial, and thyroid carcinoma [ , , , , , , , , , , , , , ] and with the last steps of hepatocellular transformation [ , ]. they often occur with or after mutations in pathways associated with cell growth and proliferation. in gbm, tertp mutations coexist with
the association of tertp mutations with shortened telomeres and with age as in ptc, melanoma, and gbm/glioma, since cells from younger patients or with sufficiently long telomeres do not need to rely on telomerase reactivation to overcome telomeric crisis [ , , , , , , , ]. partial telomere healing...
https://www.mdpi.com/2073-4409/9/3/749/htm
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