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treg细胞就是调节性t细胞(regulatory t cells),是免疫系统中的基本细胞,是sakaguchi等人[ ]于 发现的,以表达 foxp 、 cd 、 cd 为细胞表型特征。它是th 、th 、th 之外的t细胞亚群,属于一类增殖能力较低的cd + t细胞亚群,具有免疫抑制作用,能够分泌 il- 、 il- 和 tgf-β 等细胞因子,在免疫稳态和诱导免疫耐受中发挥重要作用。treg细胞在感染、肿瘤、器官移植、预防自身免疫疾病、维持机体免疫平衡等方面具有重要作用。
references [ ] sakaguchi s, sakaguchi n, asano m, et al. immunologic self-tolerance maintained by activated t cells expressing il- receptor alpha-chains (cd ). breakdown of a single mechanism of self-tolerance causes various autoimmune diseases [j]. the journal of immunology, , ( ): . [ ] gavin m a,...
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