activated in many tumor types including melanoma, lung, pancreatic and colorectal cancers. while inhibitors of raf and mek have been successfully developed and are now commercially available, to date no inhibitor of erk is available commercially. given the importance of this pathway in oncogenic signalling...
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developmental biology immunology and inflammation muscle function and homeostasis require cytokine inhibition of akt activity in drosophila katrin kierdorf et al. a cytokine partly derived from macrophages is required to promote normal muscle health and metabolism by inhibiting the activity of the insulin signalling...
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